解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene-phenotype associations. While CRISPR/Cas9-mediated null allele production in mice is highly efficient, generation of conditional alleles has...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0529-0
更新日期:2018-06-21 00:00:00
abstract:BACKGROUND:Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tregs is of great interest, and first-in-man trials of Treg transfer have achieved promising outcomes. ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0518-3
更新日期:2018-05-07 00:00:00
abstract:BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0501-z
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carried out. RESULTS:Through an RNA interference screen, and using a prosta...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0489-4
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent advantages relative to green fluorescent protein-based GECIs due to the longer wavelength light u...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0480-0
更新日期:2018-01-16 00:00:00
abstract::The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/s12915-017-0476-1
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA sequences found throughout their genomes. These have been recalcitrant to most genome sequencing met...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0473-4
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents. METHODS:Here, we translated the EPM to humans using mixed reality through a co...
journal_title:BMC biology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12915-017-0463-6
更新日期:2017-12-21 00:00:00
abstract:BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0456-5
更新日期:2017-12-07 00:00:00
abstract::The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/s12915-017-0449-4
更新日期:2017-11-16 00:00:00
abstract:BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0445-8
更新日期:2017-11-08 00:00:00
abstract:BACKGROUND:Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability and their exploi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0440-0
更新日期:2017-10-30 00:00:00
abstract:BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0419-x
更新日期:2017-09-19 00:00:00
abstract:BACKGROUND:Accurate determination of mouse positions from video data is crucial for various types of behavioral analyses. While detection of body positions is straightforward, the correct identification of nose positions, usually more informative, is far more challenging. The difficulty is largely due to variability in...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0377-3
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory response thresholds are modulated by internal and external cues to adapt odor-guided behaviors to ch...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-017-0374-6
更新日期:2017-05-05 00:00:00
abstract:BACKGROUND:The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle. Several types of proteins have been proposed to confer specificity to this process, and we have recently shown that a set of coiled-coil proteins on ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0345-3
更新日期:2017-01-26 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evolution, and vaccine efficacy. We studied this process within 2091 H3N2 full genomes utilizing a combinat...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0337-3
更新日期:2016-12-29 00:00:00
abstract:BACKGROUND:Collective neural crest cell migration is critical to the form and function of the vertebrate face and neck, distributing bone, cartilage, and nerve cells into peripheral targets that are intimately linked with head vasculature. The vasculature and neural crest structures are ultimately linked, but when and ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0323-9
更新日期:2016-12-15 00:00:00
abstract:BACKGROUND:Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabdit...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0334-6
更新日期:2016-12-07 00:00:00
abstract:BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0318-6
更新日期:2016-10-25 00:00:00
abstract::A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosquitoes transmitting disease. Despite decades of research, we know remarkably little about how it exerts its ...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/s12915-016-0312-z
更新日期:2016-10-19 00:00:00
abstract:BACKGROUND:Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tiss...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0311-0
更新日期:2016-10-06 00:00:00
abstract:BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0299-5
更新日期:2016-09-02 00:00:00
abstract:BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0286-x
更新日期:2016-08-09 00:00:00
abstract::In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0275-0
更新日期:2016-06-23 00:00:00
abstract::Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell-cell communication and the transmission of disease states, and explored as a means of drug discovery. Yet fundamental questions about their biology remain unanswered. Here I explore what exosomes are, highlight the di...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0268-z
更新日期:2016-06-13 00:00:00
abstract::The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0254-5
更新日期:2016-04-07 00:00:00
abstract:BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0233-x
更新日期:2016-03-04 00:00:00
abstract::Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0230-0
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0221-6
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolut...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0187-4
更新日期:2015-09-21 00:00:00
abstract::Malaria is a common and life-threatening disease endemic in large parts of the world. The emergence of antimalarial drug resistance is threatening disease-control measures that depend heavily on treatment of clinical malaria. The intracellular malaria parasite is particularly vulnerable during its brief extracellular ...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/s12915-015-0185-6
更新日期:2015-09-08 00:00:00
abstract:BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0176-7
更新日期:2015-08-25 00:00:00
abstract:BACKGROUND:The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut formation, the model systems Caenorhabditis elegans and Drosophila melanogaster, which belong to th...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0139-z
更新日期:2015-04-21 00:00:00
abstract::Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophag...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/s12915-015-0129-1
更新日期:2015-04-03 00:00:00
abstract:BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0122-8
更新日期:2015-02-19 00:00:00
abstract:BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-014-0113-1
更新日期:2015-01-16 00:00:00
abstract::Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...
journal_title:BMC biology
pub_type: 面试
doi:10.1186/s12915-014-0100-6
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-014-0087-z
更新日期:2014-11-12 00:00:00
abstract:BACKGROUND:Nucleolar rDNA is tightly associated with silent heterochromatin, which is important for rDNA stability, nucleolar integration, and cellular senescence. Two pathways have been described that lead to rDNA silencing in yeast: 1) the RENT (regulator of nucleolar silencing and telophase exit) complex, which is c...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-014-0075-3
更新日期:2014-09-24 00:00:00